Tom Coburn is up for re-election, but you never know with him. He made promises to be a one-termer and has also been rumored to run for Governor and as a Presidential candidate.
There are at least 35 seats up for grab this time.
Retiring Senators
Sam Brownback (R) of Kansas
Ted Kaufman (D) of Delaware
Mel Martinez (R) of Florida
Democratic incumbents
Blanche Lincoln of Arkansas
Barbara Boxer of California
Ken Salazar of Colorado
Christopher Dodd of Connecticut
Daniel Inouye of Hawaii
Barack Obama's seat of Illinois
Evan Bayh of Indiana
Barbara Mikulski of Maryland
Harry Reid of Nevada
Chuck Schumer of New York
Byron Dorgan of North Dakota
Ron Wyden of Oregon
Patrick Leahy of Vermont
Patty Murray of Washington
Russ Feingold of Wisconsin
Republican incumbents
Richard Shelby of Alabama
Lisa Murkowski of Alaska
John McCain of Arizona
Johnny Isakson of Georgia
Mike Crapo of Idaho
Chuck Grassley of Iowa
Jim Bunning of Kentucky
David Vitter of Louisiana
Kit Bond of Missouri
Judd Gregg of New Hampshire
Richard Burr of North Carolina
George Voinovich of Ohio
Tom Coburn of Oklahoma
Arlen Specter of Pennsylvania
Jim DeMint of South Carolina
John Thune of South Dakota
Bob Bennett of Utah
I am pretty sure he promised to not run for more than two terms.
But he hasn't yet decided to seek the second.
PM me to contribute to the "Guido for Senate" campaign.