Do you have a preferred chain? I made a decision last year, and am a Marriott guy now. I wish I had done that years ago, as I have several coworkers that are lifetime Platinum with them and it makes a huge difference in reservations and attention.
I am member of the 'club' in Hyatt, Marriott, and IHG - in that order. Typically, there are areas of the country where one is more 'convenient' than another due to location, pricing, number of points I already have, etc. All 3 generally will not make you sick to stay there. Some of the Hyatt's have a nice breakfast. And there is a Renaissance in downtown Milwaukee (and others) that have a great Managers evening happy hour. Free drinks and 'snacks'....generally can truly make dinner out of it.
Plus for MKE, concourse D at the airport has a little air museum that is pretty cool. Has the Medal of Honor of a local hero. That little blue ribbon is modest, but the representation is epic!
In the interest of full disclosure - I really loved staying at Holiday Inn when I was about 11. They had swimming pools!! Once I grew past the age of about 14, I realized how generally dirty these places are. And staying at hundreds of different hotels for thousands of nights over the last many of years has not given me any cause to change my opinion. Only reinforced what I found to be true, lo those many years ago. And hotel swimming pools - well, let's just say if I want to soak in a festering stew of waste and harsh chemicals, I would rather just pass - you know it's true.
Take a sleep sack with you. And pillow cover. Never walk around barefoot - get a good pair of flip-flops for use in room. Including the shower. No bare skin on any cloth surface. And the very first thing I do going into the room is turn down the bed - the sheets are gonna be dicey, but the comforter/quilt/cover is NEVER washed. Ever. You can buy a very decent poly or even silk for a very reasonable price. Keeps you off the dirty sheets....
Now, having said all that - this is also a great opportunity to build your immune system!! Positive thoughts....