Gene was very close to his wife who died of breast cancer in 1989, that was a tuff time for him.
Not even close.
After experiencing severe fatigue and suffering from pain in her upper legs on the set of Haunted Honeymoon in the United Kingdom in 1985, Radner sought medical treatment. For a period of 10 months, doctors, most of them in Los Angeles, gave her several diagnoses that all turned out to be wrong as she continued to experience pain.
During the 10 months, she faced hardships such as the publication of the highly publicized book about Saturday Night Live by Hill and Weingrad, which provided many details about her eating disorder, as well as the financial failure of Haunted Honeymoon. It grossed only $8,000,000 in the United States, entering the box office at number 8, then slipping to 14 the following week. As she wrote in It's Always Something, "On July 26 [1986], Haunted Honeymoon opened nationwide. It was a bomb. One month of publicity and the movie was only in the theaters for a week – a box-office disaster."
Finally, on October 21, 1986, Radner was diagnosed with stage IV ovarian cancer. "She immediately underwent surgery and had a hysterectomy," said a 2009 article by Jenny Song in a magazine published by the American Association for Cancer Research. "On Oct. 26," the article continued, "surgeons removed a grapefruit-size tumor from her abdomen." Then she began chemotherapy and radiation therapy treatment, as she wrote in It's Always Something, and the treatment caused extreme physical and emotional pain.
https://en.wikipedia.org/wiki/Gilda_Radnerhttp://www.imdb.com/name/nm0705717/bio?ref_=nm_ov_bio_sm